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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phenethyl Isothiocyanate
drug:
Vorinostat
Research Papers that Mention the Interaction
“By inducing protein deglutathionylation and degradation, PEITC suppressed the expression of Mcl1 in co-cultured CLL cells, and increased SAHA sensitivity.”
“The combination of SAHA and PEITC enabled the induction of marked apoptosis of CLL cells co-cultured with bone marrow stromal cells.”
Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms“Addition of β-phenylethyl isothiocyanate , a natural compound capable of depleting cellular glutathione, significantly enhanced the cytotoxicity of vorinostat in leukemia cell lines and primary leukemia cells by inhibiting the cytoprotective antioxidant response.”
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