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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Phenelzine and Vitamin B 6

supplement:

Vitamin B 6

Research Papers that Mention the Interaction

Earlier reports indicated that phenelzine treatment may result in clinically significant reductions of vitamin B6 in some individuals.
Journal of clinical psychopharmacology  •  1989  |  View Paper
Phenelzine has some clinically relevant inhibitory effects on amine oxidases, aminotransferases, and decarboxylases, and it lowers pyridoxal phosphate levels.
Journal of clinical psychopharmacology  •  2011  |  View Paper
Hydrallazine produced mixed inhibition of KAT with respect to PLP; inhibition by phenelzine increased as the PLP concentration increased, indicating that the hydrazone formed between phenelzine and PLP was a more potent inhibitor of KAT than phenelzine itself.
Biochemical pharmacology  •  1980  |  View Paper
In the direction of oxaloacetate formation a competitive inhibition was observed (Kiapp= 7.2 · 10−4M), probably due to an interaction of phenelzine with the enzyme linked pyridoxal-5'-phosphate ( PLP ) as indicated by aldimine formation of phenelzine with PLP in vitro.
Biochemical pharmacology  •  1979  |  View Paper