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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Phenacetin and Quinidine



Research Papers that Mention the Interaction

Amiodarone, bepridil, aprindine, lignocaine, flecainide and quinidine inhibited phenacetin O-deethylation in a concentration-dependent manner, although the inhibitory effects were relatively weak with IC50 values ranging from 86 to 704 microM. Propafenone and mexiletine selectively abolished the high-affinity component of phenacetin O-deethylation in human liver microsomes.
British journal of clinical pharmacology  •  1998  |  View Paper
Very much higher (1000-fold) levels of quinidine were required to inhibit the O-deethylation of phenacetin , being rather less potent in this than quinine.
British journal of clinical pharmacology  •  1986  |  View Paper