supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Pergolide elicited a potent vasopressor response in pithed rats that was highly sensitive to antagonism by the selective alpha 2-adrenoceptor antagonist, yohimbine , and resistant to blockade by the selective alpha 1-adrenoceptor antagonist, prazosin, suggesting that pergolide selectively activates postsynaptic vascular alpha 2-adrenoceptors.”
Alpha-2-adrenoceptor-mediated effects of pergolide.“The inhibitory actions of EPI, TL-99, and pergolide were blocked by the α2-adrenergic receptor antagonist yohimbine , whereas the DA receptor antagonist, sulpiride, had no effect, suggesting an action initiated at α2-adrenergic receptors.”
“Pretreatment with sulpiride but not with yohimbine completely antagonized the inhibitory effect of pergolide.”
“However, yohimbine (0.4 mg/kg) antagonized the cardiovascular effects of clonidine and reduced the bradycardia produced by pergolide.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback