supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Pergolide
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Pergolide effectively … ACTH concentration in aged horses with PPID, with similar pharmacokinetic properties as reported in young horses, including an approximate terminal half-life of 24 …. Plasma ACTH concentration increased by 50% in 3/6 horses at 2 days and 6/6 horses 10 days after discontinuing drug administration.”
Pharmacokinetic and pharmacodynamic properties of pergolide mesylate following long‐term administration to horses with pituitary pars intermedia dysfunction“After pergolide treatment, ACTH concentrations (n = 20; median = 30.4 pg/ml; range, 4.2-173) were significantly lower (P < .01) than those in horses treated with cyproheptadine (n = 7; median = 141.0 pg/ml: range, 10-1,230).”
“Among horses treated with pergolide , there was a correlation between ACTH concentration after treatment and the duration of treatment (P < .001) and pergolide dose (P = .04).”
“Although there were parallel fluctuations in the concentrations of pergolide and ACTH , timing of ACTH measurement in relation to the administration of pergolide did not have a significant effect.”
“ Pergolide and ACTH concentrations fluctuated in tandem although correlation was poor.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback