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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Pentoxifylline
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“Notably, HUVEC migration and tube formation in response to S1P were completely blocked by pretreatment with PTX.”
Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells.“These effects of S1P in MH7A cells were inhibited by pretreatment with PTX , a specific Gi/Go inhibitor.”
“ S1P stimulated extracellular signal-regulated kinase, p38 kinase, and Akt which were inhibited by PTX.”
“Activation of ERK1/2 by S1P peaked at 5 min, was sustained up to 30 min, and was blocked by PTX.”
Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells“Pretreatment with pertussis toxin PTX ; 100 ng/mlx24 h) reduced c-fos activation by S1P (100 microM-187+/-6% vs. 411+/-27%) and lysophosphatidic acid (LPA; 100 microM-90+/-34% vs. 188+/-41%), but not by sphingosylphosphorylcholine (SPC; 100 microM-390+/-47% vs. 420+/-44%).”
“ PTX pretreatment partially prevented the inhibitory effects of S1P on the NO production and iNOS induction, while completely prevented the inhibitory effects on iNOS and GTPCH mRNA expressions.”
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