supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
drug:
Pentobarbital
supplement:
Theanine
Research Papers that Mention the Interaction
“ L-THE and L-THE/PSE mixture showed increased sleep duration and shortened sleep latency when co-administrated with pentobarbital or sodium barbital.”
L-theanine and Neumentix mixture improves sleep quality and modulates brain neurotransmitter levels in mice.“2) Theanine enhanced the anticonvulsion of PB.”
“Further, theanine enhanced the anticonvulsion of PB dose-dependently against the strychnine toxicity but not the lethal toxicity of strychnine.”
“ Theanine also enhances hypnosis of pentobarbital sodium (PB) and antidepression of midazolam, suggesting there are complicated interactions between theanine and CNS drugs.”
“ Theanine enhanced both the strychnine toxicity and anticonvulsion of PB against strychnine poison.”
“ Theanine increased the power of α, β wave and decreased hypnotic ED50 of PB ; PB attenuated strychnine-induced EEG excitation and mortality with or without theanine, and theanine enhanced the effects of PB.”
“CONCLUSION Th anine ca n affect the sedative effect of low dose pen tobarbital sodium in bidirectional action style but not change the hypnosis effect.”
“Compared with normal saline, pentobarbital sodium (10 mg x kg(-1)) and the combination with theanine decreased significantly PATP (all P<0.01).”
“ Theanine enchanced hypnosis effect of pentobarbital sodium in dose-dependent manner.”
“… pentobarbital sodium (10 mg x kg(-1)), 0.25 g x kg(-1) theanine combined with that increased PATP [(25.….98)%, P<0.01)] and 0.5 g x kg(-1), 1.0 g x kg(-1) theanine could depresse that increase [(14.56 +/-…)% vs (10.08 +/- 7.98)%].”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback