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Last Updated: 2 years ago

Possible Interaction: Pentobarbital and Theanine

supplement:

Theanine

Research Papers that Mention the Interaction

L-THE and L-THE/PSE mixture showed increased sleep duration and shortened sleep latency when co-administrated with pentobarbital or sodium barbital.
Annals of palliative medicine  •  2021  |  View Paper
2) Theanine enhanced the anticonvulsion of PB.
Further, theanine enhanced the anticonvulsion of PB dose-dependently against the strychnine toxicity but not the lethal toxicity of strychnine.
Theanine also enhances hypnosis of pentobarbital sodium (PB) and antidepression of midazolam, suggesting there are complicated interactions between theanine and CNS drugs.
Theanine enhanced both the strychnine toxicity and anticonvulsion of PB against strychnine poison.
Theanine increased the power of α, β wave and decreased hypnotic ED50 of PB ; PB attenuated strychnine-induced EEG excitation and mortality with or without theanine, and theanine enhanced the effects of PB.
Drug and chemical toxicology  •  2016  |  View Paper
CONCLUSION Th anine ca n affect the sedative effect of low dose pen tobarbital sodium in bidirectional action style but not change the hypnosis effect.
Compared with normal saline, pentobarbital sodium (10 mg x kg(-1)) and the combination with theanine decreased significantly PATP (all P<0.01).
Theanine enchanced hypnosis effect of pentobarbital sodium in dose-dependent manner.
pentobarbital sodium (10 mg x kg(-1)), 0.25 g x kg(-1) theanine combined with that increased PATP [(25.….98)%, P<0.01)] and 0.5 g x kg(-1), 1.0 g x kg(-1) theanine could depresse that increase [(14.56 +/-…)% vs (10.08 +/- 7.98)%].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica  •  2009  |  View Paper