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Last Updated: 2 years ago
drug:
Pentobarbital
supplement:
Taurine
Research Papers that Mention the Interaction
“Therefore, we investigated whether the modulatory effect of taurine on γ‐aminobutyric acid (GABA)A receptors can enhance the anticonvulsive potential of the GABAA receptor agonist muscimol and of the barbiturate pentobarbital.”
Taurine potentiates the anticonvulsive effect of the GABAA agonist muscimol and pentobarbital in the immature mouse hippocampus“It was found that bicuculline and strychnine exert a blocking action on taurine-activated currents, while pentobarbital and oxazepam potentiate taurine action.”
“We conclude that taurine can be effective in attenuating the amnesia produced by alcohol, pentobarbital , cycloheximide, and sodium nitrite without compromising the behavioral aspects of the animals tested.”
“ Taurine , similar to GABA, enhanced the effects of pentobarbital on TBPS binding when present at concentrations that were otherwise ineffective on their own.”
“These findings demonstrate that pentobarbitone anaesthesia sensitises the rats to the cardiovascular effects of taurine , partially through a mechanism which involves respiratory depression.”
“These results indicate that taurine (ICV) can enhance the central depressant action of ethanol and pentobarbital and that the greatest effect of taurine occurred with LS mice in the presence of ethanol.”
“A large dose (15 mmol/kg) of intraperitoneally administered taurine lengthened the pentobarbitone induced sleep by 30%.”
“ Pentobarbitone also reduced release of taurine although the significance (if any) of this finding is obscure.”
“Release of taurine , not hitherto considered a neurotransmitter in this brain area, is depressed by muscimol (10 microM) and pentobarbitone and increased by picrotoxin (15 microM).”
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