Possible Interaction: Pentobarbital and Procaine

“Also, procaine shifted the concentration-response curve for pentobarbital in a manner expected for an additive interaction.”

“Meprobamate, sodium pentobarbitone and possibly diazepam have ganglion blocking properties while procaine , chlorpromazine, trifluoperazine, haloperidol and chlordiazepoxide reduce the ganglion potential by virtue of their preganglionic action.”

“Effects of procaine appeared to be additive with those of caffeine and pentobarbital , and are probably attained by different cellular mechanisms.”

“In agreement with a previously suggested common mechanism of action, it was found that intraperitoneal injections of convulsant doses of procaine 10 min after administration of pentobarbital produced a loss of the righting reflex in many mice not affected by the pentobarbital alone.”

“ Procaine hydrochloride (15 mg/kg) administered intravenously raises the systemic arterial pressure in spinal cats but lowers it in cats anaesthetized with pentobarbital.”

“Summary Presidon and pentobarbital administered intraperitoneally, prevent the convulsions produced by procaine in dogs, rabbits, guinea pigs, and mice.”