Possible Interaction: Pentobarbital and Calcium Supplement

“Exposure to ethanol or pentobarbital in vitro stimulated the ATP-dependent efflux of calcium from human red blood cells (RBC) and the Ca2+-ATPase activity of RBC and rat brain synaptic plasma membranes (SPM).”

“In vitro addition of ethanol or pentobarbital to synaptosomes isolated from rat or mouse brain inhibited the depolarization-dependent uptake of calcium without affecting uptake under nondepolarizing conditions.”

“These results suggest that the known inhibitory effects of ethanol and pentobarbital on the stimulated release of neurotransmitters and the development of tolerance of these effects may be mediated by the inhibition of the depolarization-dependent influx of calcium by these drugs.”

“ Calcium also increased t -butanol, chloral hydrate and pentobarbital sleeping-time and decreased the ED 50 for loss of righting reflex for ethanol, t -butanol, chloral hydrate and pentobarbital.”

“An increase in susceptibility of neuroblastoma cells to calcium was inhibited when the cells were treated with hypothermia, diphenylhydantoin, chlorpromazine or pentobarbital ; all of these treatments affect membrane permeability to calcium or membrane-associated cell metabolism.”

“ Pentobarbital and thiopental reduced the Ca2+-induced contractile effects in K+-depolarized arteries and 5-HT-Ca2+ and NA-Ca2+ contractions dose-dependently.”

“Pretreatment with pentobarbital (30 mg/kg, IP) twice daily for 2 and 6 days partially reversed this effect of calcium , suggesting that calcium and pentobarbital may in part exert their depressant effect by a similar mechanism.”

“Alternatively, pretreating mice with pentobarbital (45 mg/kg, IP) restored the antinociceptive effects of calcium.”

“The Ca++ ‐induced persistent contraction was attenuated by pretreatment with pentobarbital (10‐4 to 10‐3 mol‐1‐1) and thiamylal (10‐3 mol‐1‐1); the attenuation was greater in arteries treated with KCl than with PGF2a.”

“These results suggest that pentobarbital and thiopental may block pulmonary vasoconstriction by inhibiting calcium entry.”

“ Pentobarbital (10(-3) M) and verapamil (10(-6) M) reduced the concentration-dependent contractions induced by Ca2+ addition in control and SAH arteries previously exposed to Ca2+-free medium containing K+ or 5-HT.”