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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Pentetic Acid
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“ Fe supplementation effectively reversed the cytotoxic effects of DFO and DTPA.”
Iron chelators deferoxamine and diethylenetriamine pentaacetic acid induce apoptosis in ovarian carcinoma.“In addition, Fe(II)-mediated DMPO/.OH formation increased when the iron was chelated to either EDTA or DTPA rather than being inhibited as for Co(II).”
A comparison of cobalt(II) and iron(II) hydroxyl and superoxide free radical formation.“ DTPA significantly increased the urinary elimination of Cu, Fe , Zn, and Mn.”
“Desferal (1 mM) and Detapac (1 mM) added before iron , prevented lysozyme inactivation, while catalase (100 micrograms/ml), superoxide dismutase (100 micrograms/ml) and bovine serum albumin (100 micrograms/ml) gave about 30 to 40% protection by competing with lysozyme for iron binding.”
Mechanism of lysozyme inactivation and degradation by iron.“This activation requires oxygen, and is inhibited by free radical scavengers and by diethylene triamine pentaacetic acid , which prevents Fe cycling.”
“Chelators have been identified which selectively promote or inhibit various reactions involved in hydroxyl-radical generation (for example, NTA and EDTA promote all the reactions of both the Haber-Weiss cycle and the ascorbate-driven Fenton reaction, whereas DTPA and phytate inhibit the recycling of iron in these reactions).”
“Among the seven chelating agents tested, ethylenediamine di(o-hydroxyphenylacetic acid) and diethylenetriamine pentaacetic acid were found to almost completely inhibit ascorbate oxidation catalyzed by iron ions.”
“Chelation by DETAPAC prevented the effects of iron on 6-hydroxydopamine and 6-aminodopamine autoxidation.”
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