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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Pentetic Acid
supplement:
Ascorbate
Research Papers that Mention the Interaction
“Addition of the chelating agents EDTA and diethylenetriaminepentaacetic acid prevented both the oxidation of ascorbate and the inactivation of the enzyme.”
The analogous mechanisms of enzymatic inactivation induced by ascorbate and superoxide in the presence of copper.“Treatment with DTPA further reduced ascorbate radical signals to below quantifiable levels in most samples, further implicating the involvement of transition metal redox cycling in reactive oxygen species (ROS) formation.”
“Uptake of [3H]dopamine (250 nM) was inhibited by ascorbate (0.85 mM; −44%), and this inhibition was prevented by the iron chelator diethylenetriaminepentaacetic acid (1 mM), suggesting that ascorbate was acting as a prooxidant in the presence of iron.”
Modification of Dopamine Transporter Function: Effect of Reactive Oxygen Species and Dopamine“Among the seven chelating agents tested, ethylenediamine di(o-hydroxyphenylacetic acid) and diethylenetriamine pentaacetic acid were found to almost completely inhibit ascorbate oxidation catalyzed by iron ions.”
Stabilization of ascorbate solution by chelating agents that block redox cycling of metal ions.“ DETAPAC , EDTA and HEDTA (N-(2-hydroxyethyl)-ethylenediaminetriacetic acid) are effective at slowing the copper-catalyzed autoxidation of ascorbate while Desferal is ineffective.”
“ Diethylenetriaminepentaacetic acid (DTPA or DETAPAC) and Desferal (deferoximane mesylate) slow the iron-catalyzed oxidation of ascorbate as effectively as reducing the trace levels of contaminating iron in buffers with Chelex resin.”
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