Possible Interaction: Pentagastrin and Secretin

“ Secretin strongly inhibited basal acid output and slightly decreased pentagastrin induced gastric secretion.”

“ Pentagastrin stimulated histamine release to a peak of 168 +/- 34 ng/min, which was inhibited to 14 +/- 8 ng/min with the high concentration of secretin and to 85 +/- 21 ng/min at 40 pg/ml secretin.”

“ Secretin at an infusion rate of 10 ng/kg/min resulted in approximately 90% inhibition of gastric secretion in response to pentagastrin (20 ng/kg/min), whereas at the physiological postprandial concentration of 40 pg/ml it inhibited gastric secretion by approximately 55%.”

“The present data demonstrate that secretin , even at physiological concentrations, can inhibit gastric acid secretion in response to gastrin/pentagastrin , and one of the mechanisms of inhibition involves modulation of gastric histamine release.”

“On the other hand, secretin (100 U/kg) inhibited the trophic action of pentagastrin.”

“It is concluded that Pentagastrin may be used as a stimulant in pancreatic secretory studies.”

“ Secretin also elicited a sustained elevation in serum PG I in all four examined, including one who showed a fall in serum PG I during pentagastrin infusion.”

“ Secretin inhibited the acid response induced by pentagastrin by about 60% and simultaneously provoked a pancreatic bicarbonate output sufficient to neutralize about 60% of the gastric acid output to pentagastrin.”

“We conclude that secretin is a strong inhibitor of gastric secretion in duodenal ulcer patients induced by a meal and by pentagastrin.”

“ Secretin appeared to have a greater inhibitory effect on acid secretion stimulated by pentagastrin than on histamine-stimulated secretion.”

“The … of secretin in a dose of 1 U per kg resulted … marked inhibition of acid secretion stimulated by either pentagastrin in a dose of 0.12 μg per kg per hr or histamine acid … in a dose of 0.02 mg per kg per hr in 10 subjects.”

“ Secretin-stimulated pepsin secretion from Heidenhain pouches was significantly depressed by concomitant pentagastrin.”

“Percentage inhibition of acid output by secretin was slightly increased after vagal denervation when the stimulant was Urecholine (42% inhibition before, 52% after) or pentagastrin (63% inhibition before, 73% after), but these changes were not statistically significant.”

“In conscious cats with gastric fistulae … and pancreatic juice to jejunum, secretin (1 unit/kg-hr), cholecystokinin (CCK) (4 units/kg-hr), and duodenal …/hr) caused a marked inhibition of half maximal gastric acid response to pentagastrin (8 μg/kg-hr) but did … to histamine (160 μg/kg-hr).”

“ Secretin , CCK, and jejunal acidification prevented the formation of duodenal ulcerations in conscious cats infused with pentagastrin or histamine for 36 hours.”