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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Pentagastrin
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“The cholecystokinin (CCK-B) agonist pentagastrin stimulates dose-dependent release of adrenocorticotropin (ACTH) and cortisol in humans, likely via direct pharmacological action at pituitary CCK-B receptors.”
Effect of repeat exposure on neuroendocrine and symptom responses to pentagastrin“ Pentagastrin administration led to increases in anxiety, pulse, ACTH , cortisol and physical symptoms of panic, in a dose-related manner.”
“ Pentagastrin induced large (up to 520 % increase over baseline), significant and very rapid, dose-dependent elevations in ACTH and cortisol levels.”
“Following intracerebroventricular administration of pentagastrin, plasma corticosterone tended to decrease and in in vitro incubation of rat pituitary tissue the addition of pentagastrin elicited a suppressive effect on the ACTH release from the tissue into the medium.”
Suppressive effect of pentagastrin on pituitary-adrenocortical secretion.
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