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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Penicillins
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“This novel activation process can occur for a wide range of contaminants (cephalosporin, penicillin and tetracycline antibiotics) and ligands when coordinated with Cu(II) , and N-containing functional groups (e.g. amines) were found to form effective Cu(II) complexes for PDS activation.”
Complexation Enhances Cu(II)-Activated Peroxydisulfate: A Novel Activation Mechanism and Cu(III) Contribution.“ Penicillins , a class of widely used β-lactam antibiotics, are known to be susceptible to catalyzed hydrolysis by metal ions such as Cu(II).”
“Catalytic and complexing effect of cupric ion on the stability of penicillins was revealed in relatively lower and higher concentrations of the metal ion respectively, where an appreciable difference in the effect was noted between buffer solution and broth.”
“The logarithmic stability constants for the interaction between cupric ion and penicillins G and V were found to be 2·61 and 2·24, respectively.”
“The logarithmic stability constants for the interaction between cupric ion and penicillins G and V were found to be 2·61 and 2·24, respectively.”
“Preliminary investigations suggest that cupric ions , rather than simply complexing with penicillin as suggested by previous workers, promote the degradation of penicillin to penicilloic acid.”
“Various penicillins were found to interact with zinc and cupric ions.”
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