Possible Interaction: Penicillin G and Procaine

“Sir .—Silber and D'Angelo1 reported psychosis and seizures following the injection of penicillin G procaine in adolescents.”

“Mixtures of procaine and benzathine penicillin have been roundly condemned by every leading authority in the field and should never be used for streptococcal pharyngitis because (1) there is usually an inadequate quantity of benzathine penicillin, and (2) the procaine penicillin is needless.”

“But when 1.0 million units of procaine penicillin G, or 600,000 of both procaine plus benzathine penicillin , were used, 15% failed.”

“The implantation of the probe alone caused greater inflammatory response than the injection of procaine or procaine plus benzathine penicillin G at remote intramuscular sites.”

“Median elimination phase half-life of procaine following administration of PGP (15.6 hours) was significantly longer than value obtained after administration of penicillin G potassium and PH (1 hour).”

“Low plasma procaine esterase activity, coupled with rapid oral absorption of procaine , resulted in high urinary concentrations of the parent drug in dogs given procaine HCl or procaine penicillin G (9 mg/kg).”

“It should be stated that the conditions under which procaine and sodium penicillins were compared were not the same in the two studies.”

“ Sodium penicillin to which an equivalent weight of procaine hydrochloride has been added gives results which may be from 3 to 5 per cent lower than for the untreated penicillin.”

“It should be stated that the conditions under which procaine and sodium penicillins were compared were not the same in the two studies.”