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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Penicillin G
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“In-depth studies revealed that Cu(II) catalyzed hydrolysis of PG to benzylpenicilloic acid (PA) and oxidized PA to yield phenylacetamide and other products.”
“When benzylpenicillin (i.e., penicillin G (PG)) was exposed to Cu(II) ion at an equal molar ratio and pH 7, degradation of PG occurred rapidly in the oxygen-rich solution but gradually slowed down to a halt in the oxygen-limited solution.”
Cu(II)-catalyzed transformation of benzylpenicillin revisited: the overlooked oxidation.
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