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Possible Interaction: Penicillamine and Vitamin B 6

supplement:

Vitamin B 6

Research Papers that Mention the Interaction

[6] The d-penicillamine inhibits pyridoxine , lowering seizure threshold, or it may be related to the possible “paradoxical reaction” to excess copper mobilization.[6]
d-penicillamine … pyridoxine , lowering seizure threshold, or it may be related to the possible “paradoxical reaction” to excess copper mobilization.[6] Copper deposition in brain causes …, gliosis, laminar necrosis, spongy degeneration, and cavitation causing focal seizure activity,[6] which probable explains seizures as the initial presentation in our patient.
Neurology India  •  2012  |  View Paper
Abstract The erythrocyte alanine aminotransferase (Ala-AT) activity, measured in vitro , of rheumatoid arthritis patients under treatment with penicillamine was markedly stimulated by the addition of excess pyridoxal-5′-phosphate ( PLP).
This indicates that penicillamine can produce a deficiency of vitamin B 6 , possibly by reacting chemically with the coenzyme PLP or by inhibiting PLP synthesis.
Biochemical pharmacology  •  1981  |  View Paper
We have used the D-isomer of penicillamine rather than the racemic (DL) mixture because L-penicillamine antagonizes pyridoxal phosphate and is known to be toxic in experimental animals (Aposhian and Aposhian, 1959).
British medical journal  •  1964  |  View Paper
Examination of cellular vitamin B6 compounds showed that pyridoxal 5'-phosphate was markedly decreased when L-penicillamine was present, in agreement with the probable reaction of the inhibitor with the coenzyme.
The following findings indicated that this was because L-penicillamine caused vitamin B6 deficiency in KG980; (a) addition of excess pyridoxine significantly reversed the inhibition, (b) comparison of the growth with various concentrations of pyridoxine showed that the vitamin requirement became higher upon addition of L-penicillamine.
Acta vitaminologica et enzymologica  •  1983  |  View Paper
In addition, D-penicillamine inactivates pyridoxal-5-phosphate and gives rise to biochemical changes typical of pyridoxine deficiency in experimental animals (Asatoor, 1964) and in man (Jaffe, Altman, and Merryman, 1964).
British medical journal  •  1968  |  View Paper
Penicillamine was inhibitory at relatively low concentrations; its action was prevented by pyridoxal phosphate.
The Biochemical journal  •  1965  |  View Paper
Therefore the adverse effect of a diet free of vitamin B6 is distinctly increased by additional application of a vitamin antagonist such as D-penicillamine for instance.
Anticancer research  •  1988  |  View Paper
By itself, DPA produced a transitory decrease in both food consumption and body weight, which could be prevented with vitamin B6.
Journal of toxicology and environmental health  •  1981  |  View Paper
Simultaneous injection of vitamin B6 with D-penicillamine produced a recovery in the lowering vitamin B6 levels induced by D-penicillamine in serum and liver and enhanced the urinary excretion of Cu, but did not influence the serum content of Cu.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1980  |  View Paper
Penicillamine and thiosemicarbazide, at doses which lowered brain levels of pyridoxine by only 10%, increased seizure risk.
Psychopharmacologia  •  1975  |  View Paper