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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Penicillamine
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Intestinal resorption decreased when D-penicillamine was taken close to meals and was greatly reduced by iron preparations.”
D-penicillamine in patients with rheumatoid arthritis. Serum levels, pharmacokinetic aspects, and correlation with clinical course and side effects.“Chelation of penicillamine by iron in the gut reduces its absorption, and in these 4 patients toxicity only became apparent after iron was stopped and there was a sudden increase in penicillamine absorption.”
“Oral intake of D-penicillamine increased the excretion of Co, Cr, Fe and Mg as well.”
Urinary excretion of metals during treatment with D-penicillamine and 2-mercaptopropionylglycine in normal and cystinuric dogs.“At the same time, D-penicillamine inhibited lipid peroxidation not only by means of free radicals neutralization but also via binding of iron ions.”
“The inhibitory action of d -penicillamine is suppressed by phenylalanine, tyrosine, tryptophan, and leucine and by Cu and Fe salts.”
Selective inhibition of poliovirus growth by d-Penicillamine in vitro.
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