Possible Interaction: Pasireotide and Adrenocorticotropic Hormone

“On the other hand, the inhibitory effect of pasireotide on ACTH secretion in corticotropinoma cells seems to be mainly mediated by SST5.”

“The multiligand SOM230 pasireotide ) displays a much higher affinity for SSTR1 and SSTR5 than octreotide and suppresses ACTH secretion in cultures of human corticotroph tumors to a greater extent than octreotide.”

“Somatostatin analogs octreotide and pasireotide (SOM230) significantly suppressed CRH-induced ACTH and cAMP production in AtT20 cells and reduced ERK and p38 phosphorylation.”

“ Pasireotide potently suppresses GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease.”

“ Pasireotide otently suppresses GH, IGF-I and ACTH secretion, indicating otential efficacy in acromegaly and Cushing’s disease [7,9,12].”

“applicaion of pasireotide resulted in a stronger inhibition of ACTH nd corticosterone than octreotide [9].”

“Pasireotide binds SSTR5, the receptor expressed predominantly by corticotroph adenomas, with 40-times greater affinity than octreotide, which is consistent with the observation that pasireotide is more potent than octreotide in suppressing basal ACTH release by corticotroph adenomas.”

“ Pasireotide was shown to have long-lasting inhibitory effects on growth hormone and IGF-I release, as well as ACTH (adrenocorticotropic hormone), insulin, and to a lesser degree, glucagon.”

“SSTR5 is the predominant subtype in corticotroph adenomas, and pasireotide leads to suppression of ACTH release in Cushing’s.”

“Experimental animal studies and in vitro studies with cultured tumor cells have shown that pasireotide strongly suppresses growth hormone and adrenocorticotropin production.”