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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Parthenolide and Selenocysteine

Research Papers that Mention the Interaction

PTL selectively targets the selenocysteine residue in TrxR1 to inhibit the enzyme function, and further shifts the enzyme to an NADPH oxidase to generate superoxide anions, leading to reactive oxygen species accumulation and oxidized thioredoxin.
The Journal of Biological Chemistry  •  2016  |  View Paper