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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Paromomycin and Magnesium Cation

Research Papers that Mention the Interaction

Paromomycin binding , unlike dihydrostreptomycin binding, is independent of changes in ribosome concentration but influenced by magnesium ion concentration.
European journal of biochemistry  •  1976  |  View Paper
Paromomycin, at the ribosomal level, prevents the attachment of amino acyl-…-RNA and causes accumulation of m-RNA.Divalent cations (Ca++ and Mg++ ) antagonize the bactericidal action of paromomycin and interfere with the in vivo binding of the antibiotic on both the cell surface and the intracellular binding sites.
Canadian journal of microbiology  •  1966  |  View Paper