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Last Updated: 2 years ago

Possible Interaction: Pargyline and Tryptophan

supplement:

Tryptophan

Research Papers that Mention the Interaction

L-tryptophan (150 mg/kg) given to a pargyline (50 mg/kg) pretreated rat produces a syndrome consisting of tremor, rigidity, forepaw treading and head weaving.
European journal of pharmacology  •  1974  |  View Paper
Tryptophan modulated effects of several drugs on neuronal firing rates, including a selective 5-HT(1A) receptor antagonist (WAY-100635), a monoamine oxidase inhibitor ( pargyline ), a selective serotonin reuptake inhibitor (fluoxetine), and a serotonin-releasing agent (methylenedioxymethamphetamine).
European journal of pharmacology  •  2008  |  View Paper
Measures of behavioral activity in adulthood were taken after treatment with saline, pargyline, l-tryptophan, or pargyline given 30 min before l-tryptophan.
The combined treatment of pargyline plus l-tryptophan produced hyperactivity in controls and this effect was blocked in the 6-OHDA-treated animals.
Psychopharmacology  •  2004  |  View Paper
Pargyline (50 mg/kg) followed by low doses (20–50 mg/kg) of tryptophan caused a behavioral syndrome consisting of tremor, hindlimb abduction, forepaw treading, and straub tail.
The same dose of pargyline followed by higher doses (60–150 mg/kg) of tryptophan produced a short hypothermia followed by a dose-dependent behavioral syndrome, hyperthermia, and mortality.
Psychopharmacology  •  2004  |  View Paper
When the animals were treated with pargyline and L-tryptophan to enhance the 5-HT in the neurons, the number of 5-HT-IM neurons increased in both lines of rats.
Alcohol  •  1994  |  View Paper
However, pretreatment in vivo and in vitro with L-tryptophan and pargyline resulted in the localization of a sparse population of 5-HT fibers.
The Journal of neuroscience : the official journal of the Society for Neuroscience  •  1988  |  View Paper
The level of 5-HT in the brain was increased by pretreatment of animals with pargyline and L-tryptophan.
The Journal of neuroscience : the official journal of the Society for Neuroscience  •  1983  |  View Paper
Low doses of both tryptamine and 5-hydroxytryptamine, in the presence of pargyline , increase the activities of tyrosine and tryptophan aminotransferases and phosphoenol- pyruvate carboxykinase; these effects are distinct from those of the parent aminoacid.
Biochemical pharmacology  •  1979  |  View Paper
However, combined administration of pargyline and tryptophan resulted in a dramatic attenuation of the response and this effect was completely blocked by pretreatment with p-chlorophenylalanine.
In addition to reducing the duration of tonic immobility, combined administration of pargyline and tryptophan produced a complex behavioral syndrome which may be analogous to that observed in mammals after similar drug treatment.
Pharmacology Biochemistry and Behavior  •  1979  |  View Paper
It was also established that L-tryptophan could stimulate pituitary-adrenal activity in animals pretreated with the monoamine oxidase (MAO) inhibitor pargyline.
Neuroendocrinology  •  1978  |  View Paper