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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Para-aminobenzoic acid (PABA)
drug:
Trimethoprim
Research Papers that Mention the Interaction
“ Trimethoprim inhibits competitively the enzyme dihydrofolic acid reductase, which converts dihydrofolic acid to tetrahydrofolic acid, a stage in the synthesis of purines and ultimately of D.N.A. This stage is preceded by the incorporation of para-aminobenzoic acid into dihydropteroate, a reaction which is competitively inhibited by sulphonamides.”
Anonymous mycobacteriosis.
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