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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Para-aminobenzoic acid (PABA)
drug:
Sulfamethoxazole
Research Papers that Mention the Interaction
“ SMX inhibits the folic acid pathway through competition with para-aminobenzoic acid (pABA), one of the two substrates of the dihydropteroate synthase (DHPS), a key enzyme in de novo folic acid synthesis.”
Linking Pneumocystis jiroveci sulfamethoxazole resistance to the alleles of the DHPS gene using functional complementation in Saccharomyces cerevisiae.“The anti-Aspergillus effect depended on not TMP but SMX and that was inhibited by p-aminobenzoic acid (PABA).”
“However, it was recently demonstrated that SMX acts instead by competing with paraaminobenzoic acid ( PABA ) for ligation with H2-HMPt-P2 (Fig. 1) (3, 4).”
Subversion of Metabolic Wasting as the Mechanism for folM-Linked Sulfamethoxazole Resistance“ pABA levels were found to increase upon exposure to SMX following an exponential rise to a maxima regression model in a concentration-dependent manner.”
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