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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Para-aminobenzoic acid (PABA) and Sulfamethoxazole

Research Papers that Mention the Interaction

SMX inhibits the folic acid pathway through competition with para-aminobenzoic acid (pABA), one of the two substrates of the dihydropteroate synthase (DHPS), a key enzyme in de novo folic acid synthesis.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases  •  2010  |  View Paper
The anti-Aspergillus effect depended on not TMP but SMX and that was inhibited by p-aminobenzoic acid (PABA).
Biological & pharmaceutical bulletin  •  2005  |  View Paper
However, it was recently demonstrated that SMX acts instead by competing with paraaminobenzoic acid ( PABA ) for ligation with H2-HMPt-P2 (Fig. 1) (3, 4).
mBio  •  2017  |  View Paper
pABA levels were found to increase upon exposure to SMX following an exponential rise to a maxima regression model in a concentration-dependent manner.
Environmental science & technology  •  2008  |  View Paper