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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Para-aminobenzoic acid (PABA) and Sulfadoxine

Research Papers that Mention the Interaction

Sulfadoxine activity … p-aminobenzoic but not by p-aminobenzoylglutamic acid, and antagonised markedly by folic acid at concentrations above 4 X 10(-8) M. At 10(-7) …, a concentration lower than that of normal RPMI medium 1640, sulfadoxine activity was reduced 7000 to 9000-fold in comparison with controls.
Molecular and biochemical parasitology  •  1985  |  View Paper
Sulphadoxine (which blocks PABA uptake) had the opposite action, reducing the numbers of oocysts either when fed directly to the mosquitoes or to the donor mice.
Annals of tropical medicine and parasitology  •  1980  |  View Paper
The antimalarial activity of sulforthomidine was inhibited by folic acid and p-aminobenzoic acid.
Experimental parasitology  •  1967  |  View Paper
The apparent difference in drug sensitivity was shown to be caused by competition between 4-aminobenzoic acid and sulfadoxine.
Bulletin of the World Health Organization  •  1982  |  View Paper