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Possible Interaction: Para-aminobenzoic acid (PABA) and Sulfadiazine

Research Papers that Mention the Interaction

In accordance with our conclusions is the finding of Fox et al (1976) that zinc sulphadiazine was partially blocked by p-aminobenzoic acid (sulphadiazine is blocked) in contrast with silver sulphadiazine which is not blocked.
The Journal of pharmacy and pharmacology  •  1981  |  View Paper
FIGURE 1 shows that the inhibitory effect of sulfadiazine on the growth of the agent of mouse pneumonitis was competitively reversed by p-aminobenzoic and non-competitively by pteroylglutamic acid.
Reversal of inhibition was first observed when the molar ratio of sulfadiazine to p-aminobenzoic acid fell below 64:l and was complete a t a ratio of 8: 1.
Annals of the New York Academy of Sciences  •  1962  |  View Paper
P-aminobenzoic acid was found to counteract the inhibitory action of sulfadiazine allowing for the recovery of psittacosis virus when the virus was suspended in materials containing the sulfonamide and injected into eggs.
The injection of the p-aminobenzoic acid could be delayed up to 24 hours when injected in 1 mg amounts after a virus suspension containing 10 mg of sulfadiazine.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1949  |  View Paper
Para-aminobenzoic acid was found to be a highly effective antagonist of sulfadiazine with this virus in eggs, and a competitive relationship was suggested.
The Journal of laboratory and clinical medicine  •  1948  |  View Paper
The same concentration of p-aminobenzoic acid reversed the sulfadiazine inhibition of both mutant and wild-type parasites even though much higher concentrations of sulfadiazine were used to inhibit the mutant.
Experimental parasitology  •  1992  |  View Paper
Later Greenberg (1949) showed that other compounds are synergistic with proguanil and that these drugs, like sulfadiazine , are all inhibitors of p-aminobenzoic acid.
The Journal of parasitology  •  1963  |  View Paper
After the discovery that the 6BC strain of the psittacosis virus was … sulfadiazine (Early and Morgan, 1946a,b), Morgan (1948a,b) found that PABA definitely antagonized … action of sulfadiazine on this virus in eggs and that the chemotherapeutic action … sulfadiazine was also reversed by pteroic acid and pteroylglutamic acid.
Journal of bacteriology  •  1949  |  View Paper
p Aminobenzoic acid c ompletely antagonized the effect of su lfadiazine a nd partially antagonized the effect of pyrimethamine.
The American journal of tropical medicine and hygiene  •  1960  |  View Paper
Summary The chemotherapeutic action of sulfadiazine on psittacosis virus (strain 6BC) is antagonized competitively by p-aminobenzoic aoid and noncompetitively by pteroylglutamic acid.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1948  |  View Paper
p-Aminobenzoic and pteroic acids antagonize the inhibition of the growth of psittacosis virus (strain 6BC) by sulfadiazine in a competitive manner.
The Journal of experimental medicine  •  1948  |  View Paper