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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Para-aminobenzoic acid (PABA)
drug:
Sulfadiazine
Research Papers that Mention the Interaction
“In accordance with our conclusions is the finding of Fox et al (1976) that zinc sulphadiazine was partially blocked by p-aminobenzoic acid (sulphadiazine is blocked) in contrast with silver sulphadiazine which is not blocked.”
An investigation of the comparative liposolubilities of β‐adrenoceptor blocking agents“FIGURE 1 shows that the inhibitory effect of sulfadiazine on the growth of the agent of mouse pneumonitis was competitively reversed by p-aminobenzoic and non-competitively by pteroylglutamic acid.”
“Reversal of inhibition was first observed when the molar ratio of sulfadiazine to p-aminobenzoic acid fell below 64:l and was complete a t a ratio of 8: 1.”
“ P-aminobenzoic acid was found to counteract the inhibitory action of sulfadiazine allowing for the recovery of psittacosis virus when the virus was suspended in materials containing the sulfonamide and injected into eggs.”
“The injection of the p-aminobenzoic acid could be delayed up to 24 hours when injected in 1 mg amounts after a virus suspension containing 10 mg of sulfadiazine.”
“ Para-aminobenzoic acid was found to be a highly effective antagonist of sulfadiazine with this virus in eggs, and a competitive relationship was suggested.”
“The same concentration of p-aminobenzoic acid reversed the sulfadiazine inhibition of both mutant and wild-type parasites even though much higher concentrations of sulfadiazine were used to inhibit the mutant.”
Toxoplasma gondii: characterization of a mutant resistant to sulfonamides.“Later Greenberg (1949) showed that other compounds are synergistic with proguanil and that these drugs, like sulfadiazine , are all inhibitors of p-aminobenzoic acid.”
“After the discovery that the 6BC strain of the psittacosis virus was … sulfadiazine (Early and Morgan, 1946a,b), Morgan (1948a,b) found that PABA definitely antagonized … action of sulfadiazine on this virus in eggs and that the chemotherapeutic action … sulfadiazine was also reversed by pteroic acid and pteroylglutamic acid.”
“p Aminobenzoic acid c ompletely antagonized the effect of su lfadiazine a nd partially antagonized the effect of pyrimethamine.”
The effect of metabolites on the antitoxoplasmic action of pyrimethamine and sulfadiazine.“Summary The chemotherapeutic action of sulfadiazine on psittacosis virus (strain 6BC) is antagonized competitively by p-aminobenzoic aoid and noncompetitively by pteroylglutamic acid.”
“ p-Aminobenzoic and pteroic acids antagonize the inhibition of the growth of psittacosis virus (strain 6BC) by sulfadiazine in a competitive manner.”
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