Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Para-aminobenzoic acid (PABA) and Pyrimethamine

Research Papers that Mention the Interaction

The use of the standard RPMI medium or RPMI medium containing low concentrations of folate and para-aminobenzoic acid increases the 50% inhibitory concentrations of cycloguanil and pyrimethamine , as compared with the use of folate- and para-aminobenzoic acid-free RPMI medium.
Bulletin de la Societe de pathologie exotique  •  1999  |  View Paper
Low level antagonism of pyrimethamine resulted from the inclusion of p-aminobenzoic acid , p-aminobenzoylglutamic acid or folic acid in the test medium.
Molecular and biochemical parasitology  •  1985  |  View Paper
Reversal experiments with PABA and synergism studies with pyrimethamine indicated that both compounds interfered with the PABA-folic acid metabolic sequence.
The Journal of protozoology  •  1967  |  View Paper
In addition, the effect of pyrimethamine on the synthesis of folic acid from p-aminobenzoic acid has been invcstigatrd.
The Journal of biological chemistry  •  1959  |  View Paper