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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Para-aminobenzoic acid (PABA)
drug:
Pyrimethamine
Research Papers that Mention the Interaction
“The use of the standard RPMI medium or RPMI medium containing low concentrations of folate and para-aminobenzoic acid increases the 50% inhibitory concentrations of cycloguanil and pyrimethamine , as compared with the use of folate- and para-aminobenzoic acid-free RPMI medium.”
[Variability of in vitro activity of proguanil and cycloguanil on erythrocyte stages of Plasmodium falciparum as a function of culture conditions].“Low level antagonism of pyrimethamine resulted from the inclusion of p-aminobenzoic acid , p-aminobenzoylglutamic acid or folic acid in the test medium.”
Antagonism of sulfadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid.“Reversal experiments with PABA and synergism studies with pyrimethamine indicated that both compounds interfered with the PABA-folic acid metabolic sequence.”
“In addition, the effect of pyrimethamine on the synthesis of folic acid from p-aminobenzoic acid has been invcstigatrd.”
Effect of pyrimethamine on folic acid metabolism in Streptococcus faecalis and Escherichia coli.
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