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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Para-aminobenzoic acid (PABA)
drug:
Platinum
Research Papers that Mention the Interaction
“The administration of PABA in rats was followed by a substantial reduction in total urinary excretion of platinum (P < 0.05) and by a significant (P < 0.01) lower concentration of DDP derived platinum in the urine collected during the first 4 h after treatment.”
“The combined treatment with PABA produced a significant increase in the plasma concentrations of total platinum , without affecting the levels of platinum species in the plasma ultrafiltrate.”
“Total 24-h urinary excretion of platinum was also decreased, although not significantly, by PABA.”
Effect of para-aminobenzoic acid on the pharmacokinetics and urinary excretion of cis-diamminedichloroplatinum(II) in rats.
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