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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Para-aminobenzoic acid (PABA)
drug:
Methotrexate
Research Papers that Mention the Interaction
“Folic acid and amethopterin competitively inhibited the acetylation of p -aminobenzoic acid , with respective K i values of 0.01 mM and 0.06 mM. It is concluded that the activity of N -acetyltransferase in human blood may have important clinical implications.”
Acetylation of p-aminobenzoic acid by human blood.“4) The presence of aromatic amines such as p-aminobenzoic acid , diminished the formation of the inactive derivative from A-methopterin possibly through competitive inhibition.”
DETOXICATION OF A-METHOPTERIN AND AMINOPTERIN BY THE ACETYLATING ENZYME OF LIVER.
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