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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Para-aminobenzoic acid (PABA) and Glycine

Research Papers that Mention the Interaction

The I50 values, the concentration of the inhibitor that leads to 50% inhibition of glycine conjugation of PABA as compared to the control, have been determined for sulfamoyl benzoic acids, sulfonamides, and penicillins.
Therefore, it can be concluded that the inhibition in vitro of the glycine conjugation of PABA is a useful model for the estimation of tubular secretion and drug interaction potential of acidic drug molecules in this process in vivo.
Journal of pharmaceutical sciences  •  1998  |  View Paper
The I50 values, the concentration of the inhibitor that leads to 50% inhibition of glycine conjugation of PABA as compared to the control, have been determined for sulfamoyl benzoic acids, sulfonamides, and penicillins.
Therefore, it can be concluded that the inhibition in vitro of the glycine conjugation of PABA is a useful model for the estimation of tubular secretion and drug interaction potential of acidic drug molecules in this process in vivo.
Journal of pharmaceutical sciences  •  1998  |  View Paper
Summary ‘Benemid', p-(di-n-propylsul-famyl)-benzoic acid, inhibits the conjugase responsible definitively for the over-all reaction involved in the conjugatior of glycine with p-aminobenzoic acid.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1950  |  View Paper