Possible Interaction: Para-aminobenzoic acid (PABA) and Ciprofloxacin

“These findings indicate a potential usefulness for the synergistic combinations against P. aeruginosa and S. aureus in … clinical situation; that is, they indicate an extended role for sulphonamides and support a potential role for p‐aminobenzoic acid as enhancers of the activity … primary antibacterial agents such as ciprofloxacin and ….”

“ p‐Aminobenzoic acid plus either ciprofloxacin or polymyxin also demonstrated enhanced killing activity against P. aeruginosa but these combinations were less effective in enhancing activity against S. aureus.”