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Possible Interaction: Para-aminobenzoic acid (PABA) and Aminosalicylic Acid

Research Papers that Mention the Interaction

Durham and Hubbard (1959) suggested that p-aminosalicylic acid influenced the assimilation of p-aminobenzoic acid by competing with the substrate for the specific transport mechanism(s) in the cell membrane thereby controlling oxida-
More recently, Hedgecock (1958) demonstrated that p-aminobenzoic acid competitively antagonized the inhibitory effect of p-aminosalicylic acid on the growth of Mycobacterium tuberculosis.
Results obtained from additional investigations indicated that the utilization of p-aminobenzoic acid as a sole source of energy for aerobic growth is also competitively inhibited by paminosalicylic acid (Durham, 1957).
Journal of bacteriology  •  1960  |  View Paper
That para-aminobenzoic acid antagonizes competitively the inhibitory effect of paraaminosalicylic acid on the growth of Mycobacterium tuberculosis is well known.
Journal of bacteriology  •  1958  |  View Paper
It is known that intrinsic metabolites, such as, para-aminobenzoic acid (PABA) and methionine, antagonize PAS and structurally related anti-folate drugs.
Front. Cell. Infect. Microbiol.  •  2018  |  View Paper
Based on the observation that exogenously supplied p-aminobenzoic acid (PABA) can antagonize the action of antifolates that interact with dihydropteroate synthase (DHPS), such as sulfonamides and p-aminosalicylic acid (PAS), we hypothesized that bacterial PABA biosynthesis contributes to intrinsic antifolate resistance.
Herein, we demonstrate that disruption of PABA biosynthesis potentiates the anti-tubercular action of DHPS inhibitors and PAS by up to 1000 fold.
Scientific reports  •  2016  |  View Paper
(This could account for why p-aminobenzoic acid , but not salicylic acid, antagonizes the action of p-aminosalicylic acid.)
This could account for why p-aminobenzoic acid , but not salicylic acid, antagonizes the action of p-aminosalicylic acid.)
Biochimica et biophysica acta  •  1975  |  View Paper
Antagonistic effects of PABA on the tuberculostatic activities of synthesized ω-substituted alkyl esters of PAS were examined.
Chemical & pharmaceutical bulletin  •  1967  |  View Paper
Utilization of p-aminobenzoic acid as an oxidizable substrate by a Flavobacterium4 is competitively inhibited by p-aminosalicylic acid5 , and it has been suggested that p-aminosalicylic acid competes with the substrate for the specific transport mechanism(s)6.
Nature  •  1963  |  View Paper
Of the three compounds previously reported to be antagonistic, only p-aminosalicylic acid influenced the oxidative dissimilation of p-aminobenzoic acid7.
Nature  •  1959  |  View Paper
Antagonism of the chemotherapeutic activity of PAS in experimental tuberculosis by dietary PABA was demonstrated.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1953  |  View Paper
The observation by Youmans et al. (1947) that para-aminobenzoic acid (PABA) antagonizes the action of para-aminosalicylic acid (PAS) has been confirmed repeatedly.
Journal of bacteriology  •  1951  |  View Paper