Possible Interaction: Papaverine and Potassium

“ Papaverine had limited antispasmodic efficacy and prevented vasoconstriction in response to potassium (60 mmol/L) and phenylephrine for only 1 hour at the longest.”

“Glyceryl trinitrate, 7.2 micrograms/mL, or papaverine hydrochloride , 11.9 micrograms/mL, caused 80% to 100% relaxation of contraction induced by potassium or thromboxane.”

“Although nifedipine was the most potent vasodilator, papaverine produced the greatest maximal inhibition of both potassium- and norepinephrine-induced contraction of human internal mammary artery.”

“The striking contraction caused by high conentration of potassium was also antagonized by acetagasstrodine and papaverine , the IC_(50) were 31.”

“Brovincamine (IC50: 1.2 x 10(-5) M), verapamil (IC50: 3.5 x 10(-7) M) or papaverine (IC50: 2.5 x 10(-5) M) caused a dose-dependent relaxation of potassium (30 mM)-contracture in the rabbit pulmonary arterial segment.”

“It is concluded that the predominant membrane effect of papaverine on the heart is to reduce the potassium conductance.”

“These results suggest that papaverine potentiated Ca-uptake by membranes such as sarcoplasmic reticulum, in the presence of potassium oxalate and inhibited Ca-uptake by the plasma membrane-derived vesicles in the absence of potassium oxalate.”

“With their single administration ornidium (30 mg/kg) and papaverine (10 mg/kg) were found to increase the electrongegative biopotential and the potassium content in the vasculr wall.”