Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“This characteristic distinguishes them from other drugs such as sodium nitroprusside, papaverine , hydralazine and diazoxide which interfere with the availability of calcium ions for their physiological functions by acting at sites other than the 'calcium channels'.”
“This characteristic distinguishes them from other drugs such as sodium nitroprusside, papaverine , hydralazine and diazoxide which interfere with the availability of calcium ions for their physiological functions by acting at sites other than the ‘calcium channels’.”
“These recent findings have led to the use of papaverin to reduce the level of intracellular calcium , alpha-blockers to antagonize alpha-receptor and prostaglandin to inhibit norepinephrine release.”
“Under our experimental conditions D 600, nifedipine and papaverine were found to act as antagonists against calcium and noradrenaline in a non-competitive fashion.”
Naunyn-Schmiedeberg's Archives of Pharmacology • 2004 | View Paper
“In vitro, reticuline, norarmepavine, coclaurine, and papaverine competitively antagonize the uterine muscular contractions induced by acetylcholine and calcium.”
Journal of pharmacobio-dynamics • 1986 | View Paper
“2 Pre‐incubation for 20 min with either ketamine (0.3 to 3 mM), papaverine (3 to 30 μM), theophylline (0.1 to 1 mM) or verapamil (3 to 30 nM) induced parallel, concentration‐dependent rightward displacements of the dose‐response curves to Ca2+ (0.04 to 22 mM).”
British journal of pharmacology • 1985 | View Paper
“From this the authors infer an interaction (complex formation) between papaverin and calcium at the phase boundary, which is independent of the biological medium.”
“When the calcium content was 1 mmol/l, papaverin increased the proneness to cramping only to a smaller degree, in agreement with the effect measured when the calcium content of the organ bath was reduced below 1 mmol/l.”
“ Papaverine was only slightly more active on contractions sustained by influx of extracellular Ca2+ (through potential‐dependent channels and receptor‐operated channels) than on those sustained by intracellular Ca2+.”