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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“Native LAF was destroyed by Streptomyces griseus protease, but not by trypsin, chymotrypsin, and papain, although in the presence of 8 M urea, papain completely destroyed LAF activity.”
Physicochemical characterization of lymphocyte-activating factor (LAF).“At 0.5 M urea concentration, the apparent thermal denaturation temperature increased from a control value … +/- 1 degrees C to 86 +/- 1 degrees C. At isopotential conditions, the partial specific volume of papain was found to be higher … of lower concentrations of urea , than the native … or unfolded molecule.”
Effect of urea at lower concentration on the structure of papain--formation of a stable molten globule and its characterization.“The GuHCl- and temperature-induced unfolding of papain , in the presence of urea , indicates stabilization of the protein as seen from the higher transition midpoints, when monitored by fluorescence and circular dichroism (CD).”
“The reduction of papain in the presence of 8 M urea leads to the partial reduction of one disulfide bond.”
“Although urea reversibly inactivates papain , high levels of guanidine hydrochloride were found to cause an irreversible inactivation, accompanied by significant unfolding of the enzyme.”
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