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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Papain and Ebselen

supplement:

Papain

supplement:

Ebselen

Research Papers that Mention the Interaction

However, in the presence of GSH, 2-mercaptoethanol or sodium borohydride, ebselen exerts an activating effect on papain.
Papain is inactivated by ebselen with a second order rate constant of 1800 M-1 sec-1 in the absence of thiols.
The binding of ebselen by a seleno-sulfide bond to cysteine residues of GSTs and papain leads to their inactivation.
Biochemical pharmacology  •  1994  |  View Paper