“However, in the presence of GSH, 2-mercaptoethanol or sodium borohydride, ebselen exerts an activating effect on papain.”
“ Papain is inactivated by ebselen with a second order rate constant of 1800 M-1 sec-1 in the absence of thiols.”
“The binding of ebselen by a seleno-sulfide bond to cysteine residues of GSTs and papain leads to their inactivation.”