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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Pantethine and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Aim To use the antioxidant compounds (sodium selenite, selenomethionine, D-pantethine ) for modulation of cytotoxic effect of doxorubicin and cisplatin toward wild type and drug-resistant mutants of several human tumor cells.
Croatian medical journal  •  2014  |  View Paper
Moreover, SeMet and D-Pt decreased several side effects of Dx , namely an elevated creatinine level in blood and monocytosis, thus normalizing health conditions of B16 melanoma-bearing animals.
Results Selenomethionine (1200 µg/kg) and D-pantethine (500 mg/kg) in combination with Dx (10 mg/kg) significantly reduced tumor-induced neutrophilia, lymphocytopenia, and leukocytosis in comparison to Dx treatment alone.
Croatian medical journal  •  2017  |  View Paper
Conclusions Antioxidants selenomethionine and D-pantethine partially reversed the negative side effects of Dx in NK/Ly lymphoma-bearing mice and significantly increased the therapeutic efficiency of this drug in tumor treatment.
Croatian medical journal  •  2016  |  View Paper