Possible Interaction: Pamidronate and Calcium Supplement

“ CA 125 tended to be lower in the long-term PD patients and also in APD patients, but statistical significance was missing.”

“These results suggest that forearm bone loss after intravenous pamidronate treatment for moderate-to-severe Paget's disease can largely be prevented by administration of calcium and calcitriol.”

“ Oral pamidronate caused a dose-related reduction on the biochemical markers of bone resorption, i.e. fasting urinary calcium , hydroxyproline, pyridinoline and deoxypyridinoline that was seen already after the first week.”

“All patients responded to APD with a rapid decrease of plasma calcium concentration from 3.44 +/- 0.10 mmol/l at day 0 to 2.33 +/- 0.06 at day 6, p less than 0.001).”

“… (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (… calcium (1 g/day) with that of calcium alone on the bone mass of patients receiving long-term glucocorticoid therapy, the mean ….2% between 0 and 6 months (p less than 0.06) and then remained stable between 6 and 12 months.”

“He was noted to have persistently high calcium , which required multiple doses of pamidronate.”

“In terms of percentage BMD change at the femoral neck, both pamidronate and ibandronate combined with calcium demonstrated a remarkable gain compared with calcium (MD, 7.02; 95% CrI, 0.30–13.29 and MD, 7.30; 95% CrI, 0.32–14.22, respectively).”

“Despite pamidronate treatment , the calcium level continued to rise.”

“Since pamidronate reduces mineral resorption from tissues, calcium and phosphate replacements increase systemic mineral deposits.”

“In the presence of calcium, pamidronate and alendronate were toxic to the cells, with pamidronate being more toxic than alendronate.”