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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Palmitic Acid
drug:
Tibolone
Research Papers that Mention the Interaction
“Our results demonstrated that tibolone attenuated lipotoxic damage of PA in normal human astrocytes by reducing PI uptake in 53%, prevented cardiolipin loss by 17%, reduced fragmented/condensed nuclei by 50.81% and attenuated the production of superoxide ions by around 20%.”
Tibolone Ameliorates the Lipotoxic Effect of Palmitic Acid in Normal Human Astrocytes“Here, we have evaluated which estrogen receptor is involved in protective actions of tibolone and analyzed whether tibolone reverses gene expression changes induced by PA.”
“It is noteworthy that tibolone attenuated the increased expression of TERT, TERC and DNMT3B genes induced by palmitic acid.”
“Previously, we demonstrated that tibolone , a synthetic steroid with estrogenic, progestogenic and androgenic actions, protects cells from mitochondrial damage and morphological changes induced by PA.”
“Although we did not find significant actions of tibolone on free radical production, it modulated astrocytic morphology after treatment with palmitic acid.”
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