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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Palmitic Acid
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“Insulin resistance induced by palmitic acid is prevented by pre-incubation of the anti-inflammatory and the ER stress release reagents, sodium salicylate and 4 phenylbutirate, respectively.”
Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells“At 3 mM salicylate , velocity at saturating palmitic acid concentration for the oxidation was decreased, but the decrease for oxidation to CO2 was smaller than for total oxidation.”
“Velocity calculated at saturating palmitic acid concentration for total oxidation was slightly increased by 0.75 mM salicylate , but the increase for oxidation to CO2 was larger.”
“In the same preparation, salicylate had no effect … the oxidation of palmitoylcarnitine or palmitoyl-CoA. Salicylate appears to augment the initial step of palmitic acid oxidation by lowering the apparent Michaelis constant (Km) of long chain fatty acid: CoASH ligase (AMP) (EC 6.2.1.3) for palmitic acid.”
“ Salicylic acid , in concentrations that exerted no effect on mitochondrial coupling (0.1 mM), significantly stimulated mitochondrial palmitic acid oxidation , with maximal stimulation occurring at subsaturating concentrations of substrate.”
“ SA particularly increased the percentage of linolenic acid and lowered that of palmitic acid by the same proportion.”
Effects of exogenous salicylic acid pre-treatment on cadmium toxicity and leaf lipid content in Linum usitatissimum L.
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