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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Palmitic Acid
supplement:
Resveratrol
Research Papers that Mention the Interaction
“This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactive oxygen species (ROS) and further explored the underlying molecular mechanisms.”
Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway“In conclusion, our results show that Resv protect cardiomyocytes from contractile dysfunction induced by PA.”
“Our results show that PA (200 µM) decreased the rate of cardiomyocyte relaxation, reduced the number of rod shaped cardiomyocytes and increased the number of cells with condensed nuclei; pre-treating cardiomyocytes with Resv significantly prevented these changes.”
“SERCA2a activity assay showed that Vmax and iono ratio was increased with PA and pre-treatment with Resv prevented this increase.”
Resveratrol prevents palmitic acid induced cardiomyocyte contractile impairment.“Although PA reduced CD36 and increased GLUT4 metabolic pathway proteins, when we pretreated cells with resveratrol to activate SIRT1 or transfected si-PKCζ, both were able to significantly increase CD36 metabolic pathway proteins and reduce GLUT4 pathway proteins.”
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