Possible Interaction: Palmitic Acid and Polyunsaturated Fatty Acids

“The proportions of the polyunsaturated phosphatidylcholine species, 16:0 -20:4 (10.0 +/- 0.7%) and 16:0-22:6 (7.1 +/- 0.8%), were both significantly higher than those in healthy controls (7.6 +/- 0.5%, P < 0.01 and 5.3 +/- 0.5%, P < 0.05 respectively).”

“The surface response analysis suggested that the effect of palmitic acid on TG is blunted in different degrees according to the PUFA chemical structure.”

“Since mutagenic metabolites can be formed from peroxidation of polyunsaturated fatty acids, co-administration of palmitic and a polyunsaturated fatty acid might be particularly harmful.”

“However, it remains unclear if n-3 PUFAs are capable of antagonizing the synergistic effect of LPS and PA on gene expression and CER production.”

“ PAM caused a decrease in polyunsaturated fatty acid ( PUFA ) content and an increase in saturated fatty acid content in the mitochondrial membrane, while EPA was incorporated in the mitochondrial membrane and caused a significant increase in the PUFA content.”

“All the groups had similar levels of plasma cholesterol, but the LDL levels were significantly lower in the group fed with palmitic acid plus PUFA.”

“The inclusion … of PUFA in the … in palmitic acid substantially modified the LDL receptor response in the lymphocytes, suggesting that the proportion of different families of dietary fatty acids … more important than the individual amount of each in absolute terms to explain their effects on plasma lipids and lipoproteins.”

“Treatments containing polyunsaturated fatty acids decreased palmitic acid metabolism to TG and total cellular lipids compared with treatments 2C16 and C18:1.”

“ Palmitic and stearic acid plasma levels were significantly reduced (P < 0.05) after ω-3PUFA.”