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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Palmitic Acid
Research Papers that Mention the Interaction
“In particular, metabolic products of palmitic acid affect the activation of various PKCs, ER stress and cause an increase in ROS generation.”
The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms“Conversely, prolonged treatment with PA (24 h) induced ER stress and cell death together with a blockade of the autophagic flux.”
“Further, PA treatment significantly increased the expression of ERS markers, Ig heavy chain binding protein (Bip), and homologous proteins of CCAAT-enhancer binding proteins (CHOP).”
“ PA enhanced the levels of proteins related to apoptosis, necroptosis, autophagy, and ER stress.”
“Results of Western blot analysis and 3-(4,5-…)-2,5-diphenyltetrazolium bromide (MTT) assay revealed that palmitic and stearic acid reduced … viability and induced extreme ER stress by increasing the protein expression of ER stress markers, such as … endoplasmic reticulum kinase, phospho-eIF2α, cleaved CASP-3, and CHOP.”
Effects of fatty acids on inducing endoplasmic reticulum stress in bovine mammary epithelial cells.“The results showed that PA inhibits cell viability and estradiol secretion through inducing ER stress and cAMP/PKA/CREB pathway.”
“We tested the hypothesis that PA increases susceptibility to lung epithelial cell death and experimental fibrosis by modulating ER stress.”
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