Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Paclitaxel and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

In H1299 cells, the anticancer effects of the combinational treatment with paclitaxel and ascorbic acid were up to 1.7-foldhigher than those of single-agent paclitaxel treatment.
Taken together, these results suggest that combinational chemotherapy with ascorbic acid and paclitaxel not only does not block the anticancer effects of paclitaxel but also alleviates the cytotoxicity of paclitaxel in vivo and in vitro.
Nutrition research  •  2012  |  View Paper
Moreover, ascorbic acid also attenuated the cytotoxicity induced by paclitaxel.
Cancer Chemotherapy and Pharmacology  •  2004  |  View Paper
The neuronal death induced by taxol was significantly attenuated not only by anti-apoptotic drugs such as z-VAD-fmk and cycloheximide but also by antioxidants such as trolox, ascorbic acid and tempol.
Neuroscience Letters  •  2008  |  View Paper
The reduction kinetics of nitroxides by ascorbic acid showed that paclitaxel can inhibit the reaction by blocking the diffusion of either the ascorbic acid or nitroxide molecules since the reaction is tested to be a first order one.
International journal of pharmaceutics  •  2007  |  View Paper
20067 Background: We had earlier … that antioxidants (beta carotene, vitamins C and E) enhance … apoptotic effect of paclitaxel and carboplatin in vitro and there was a suggestion that when used as an adjunct to … above chemotherapeutic agents in patients with NSCLC, they might enhance the efficacy of the latter.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology  •  2006  |  View Paper