Possible Interaction: Paclitaxel and Vitamin C

“In H1299 cells, the anticancer effects of the combinational treatment with paclitaxel and ascorbic acid were up to 1.7-foldhigher than those of single-agent paclitaxel treatment.”

“Taken together, these results suggest that combinational chemotherapy with ascorbic acid and paclitaxel not only does not block the anticancer effects of paclitaxel but also alleviates the cytotoxicity of paclitaxel in vivo and in vitro.”

“Moreover, ascorbic acid also attenuated the cytotoxicity induced by paclitaxel.”

“The neuronal death induced by taxol was significantly attenuated not only by anti-apoptotic drugs such as z-VAD-fmk and cycloheximide but also by antioxidants such as trolox, ascorbic acid and tempol.”

“The reduction kinetics of nitroxides by ascorbic acid showed that paclitaxel can inhibit the reaction by blocking the diffusion of either the ascorbic acid or nitroxide molecules since the reaction is tested to be a first order one.”

“20067 Background: We had earlier … that antioxidants (beta carotene, vitamins C and E) enhance … apoptotic effect of paclitaxel and carboplatin in vitro and there was a suggestion that when used as an adjunct to … above chemotherapeutic agents in patients with NSCLC, they might enhance the efficacy of the latter.”