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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Paclitaxel
supplement:
Tocophersolan
Research Papers that Mention the Interaction
“Moreover, TPGS as part of micelle composition could enhance the therapeutic effect of PTX and reduce side effects.”
A novel mixed polymeric micelle for co-delivery of paclitaxel and retinoic acid and overcoming multidrug resistance: synthesis, characterization, cytotoxicity, and pharmacokinetic evaluation“Furthermore, TPGS 400 concentration-dependently increased the intracellular retention of Rhodamine 123 in Caco-2 cells and enhanced paclitaxel permeability in monolayer Caco-2 cultures.”
“Our results indicated that TPGS 400 enhances the oral bioavailability of paclitaxel in mice and the enhancement may result from an increase in intestinal absorption of paclitaxel.”
“The oral bioavailability of paclitaxel in TPGS 400/ethanol (7.8%) was 3-fold higher than that in Cremophor/ethanol (2.5%).”
“Aqueous solubility of paclitaxel is significantly enhanced by TPGS , where a linear increase was demonstrated above a TPGS concentration of 0.1 mg/ml.”
Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro, in situ and in vivo.“Graft and star-shaped graft polymers consisting of poly(ethylene glycol) (PEG400) graft chains increased the PTX solubility in water by three orders of magnitude.”
“Co-administration of TPGS enhanced the cytotoxicity of doxorubicin, vinblastine, paclitaxel , and colchicine in the G185 cells to levels comparable to the parental cells.”
“Using a polarized epithelial cell transport assay, TPGS blocked P-gp mediated transport of R123 and paclitaxel in a dose responsive manner.”
“Taken together, our results demonstrate that while PEG , due to its solubility in both polar and nonpolar solvents, may act as a dissolution aid for paclitaxel and piroxicam, of the three drug molecules studied it will only have a protective role for the case of the hematoporphyrin.”
Study of interaction between PEG carrier and three relevant drug molecules: piroxicam, paclitaxel, and hematoporphyrin.“In vitro drug release studies found that incorporation of TPGS considerably facilitated paclitaxel release.”
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