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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Paclitaxel
supplement:
Sulforaphane
Research Papers that Mention the Interaction
“The most striking observation was the ability of sulforaphane to potentiate the activity of several classes of anticancer agents including paclitaxel , docetaxel, and gemcitabine through additive and synergistic effects.”
Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems“Combined treatment of breast cancer cells with SFN and paclitaxel resulted in increased activation of apoptotic signaling pathway members, including caspase-3, -8 and -9, and cytochrome c, compared with treatment with SFN or paclitaxel alone.”
Sulforaphane sensitizes human breast cancer cells to paclitaxel-induced apoptosis by downregulating the NF-κB signaling pathway.“The treatment with SFN also suppressed the expression of multidrug resistance protein, reduced drug efflux, and increased anticancer activity of other antiproliferative agents including paclitaxel.”
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