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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Paclitaxel
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“Additionally, the values of binding constants and Δ G ° showed that PTX + NDs interact strongly with HSA compared to PTX or NDs alone and the hydrophobic force plays a major role in this interaction.”
The Effects of Paclitaxel in the Combination of Diamond Nanoparticles on the Structure of Human Serum Albumin (HSA) and Their Antiproliferative Role on MDA-MB-231cells“Analysis of circular dichroism, ultraviolet-visible, three-dimensional fluorescence, Fourier transform infrared and resonance light scattering spectra demonstrated that HSA conformation was slightly altered in the presence of paclitaxel and dimension of the individual HSA molecules were larger after interacting with paclitaxel.”
“Moreover, the α-helix content in HSA greatly decreased in the presence of paclitaxel as opposed when estradiol was present.”
“The quantitative analysis data of circular dichroism (CD) spectra demonstrated that the binding of paclitaxel and/or estradiol to HSA induced conformational changes in HSA.”
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