“ Kanglaite inhibited the expression of nuclear factor (NF)-κΒ and upregulated that of connexin 43, both of which sensitized cancer cells to Taxol.”
“ Kanglaite pretreatment followed by Taxol treatment was found to show the best synergism among all combination strategies.”
“Moreover, Kanglaite increased many cellular variations caused by Taxol , including tubulin polymerization, caspase-3 cleavage, and upregulated expression of survivin and cyclin B1.”
“These results suggest that Kanglaite pretreatment may increase the effect of Taxol on colorectal cancer.”