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Discover Supplement-Drug Interactions

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Last Updated: 4 years ago

Possible Interaction: Paclitaxel and Dolastatin Compound

Research Papers that Mention the Interaction

These pentapeptides have mechanism of actions similar to that of taxol, but through processes that appear opposing to each other; that is, dolastatins and auristatins inhibit tubulin polymerization, whereas taxol promotes it and stabilizes the microtubules.[3] In the end, both dolastatins or auristatins and taxol inhibit cell proliferation.
ChemMedChem  •  2011  |  View Paper