Possible Interaction: Paclitaxel and Dolastatin Compound

“These pentapeptides have mechanism of actions similar to that of taxol, but through processes that appear opposing to each other; that is, dolastatins and auristatins inhibit tubulin polymerization, whereas taxol promotes it and stabilizes the microtubules.[3] In the end, both dolastatins or auristatins and taxol inhibit cell proliferation.”